Bangkok Stem Cells
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Joint Pain Treatment - Knees, shoulder and back pain, non-surgical

Stem cell


Many famous athletes like Bartolo Colon and Tiger Woods have undergone this type of procedure with excellent results. The video shows how Adult Stem Cells and PRP can be used to treat golf related injuries to knees, shoulders and Joint Pain. A small amount of blood and abdominal fat is removed from the patient, stem cells are isolated, activated and injected into the golf injury. It usually takes about 6-8 weeks for complete healing to occur.


Fat Stem Cells Diagram for Joint Pain

MRI of Knee

Osteoarthritis (OA) is a progressive degenerative condition of articular cartilage and subchondral bone that affects 15% of the Australian population. The disease results in pain and stiffness that leads to significant physical and psychological disability, and adversely affects daily function and quality of life. Current treatment includes exercise, viscosupplementation and analgesia or anti-inflammatory medications however each of these is associated with limitations that restrict their ability to effectively arrest the condition. Consequently, there is a pressing need for novel and effective therapies to treat OA.

Recent research has demonstrated that Human adipose-derived stem cells (ADSCs) can differentiate into cartilage and bone suggesting a potential treatment in osteoarthritis (Diekman et al, 2010; Kern et al 2006). Indeed, cartilage regrowth has been shown in animal models with cartilage defects (Dragoo et al, 2007; Cui et al, 2009) and research in Humans has demonstrated its safety and efficacy in phase I and II clinical trials with up to two years follow up (Garcia-Olmo et al, 2005; Garcia-Olmo et al, 2008; Garcia-Olmo et al, 2009). Further, the sampling of cells from adipose tissue rather than bone marrow or human embryo tissue reduces the pain, complexity and ethical considerations associated with these other techniques. As such, the use of ADSCs may offer a safe and effective therapy to treat osteoarthritis and potentially reverse the progression of the disease.

RESEARCH

Photoactivated Platelet-Rich Plasma Therapy for a Traumatic Knee Chondral Lesion

Lifecare Prahran Sports Medicine Centre, Melbourne, Victoria, Australia.
Freitag J, Barnard A, Rotsein A.

Abstract

To evaluate the effect of combining photoactivation therapy with platelet-rich plasma injections in the treatment of a traumatic chondral lesion of the knee. A 38-year-old man presented with left-knee pain and swelling following a basketball injury. MRI demonstrated a full-thickness lateral tibial plateau chondral flap with subchondral cyst formation and marrow oedema. The patient underwent a course of photoactivated platelet-rich plasma (PAPRP) injections. Patient outcome measures included the numerical pain rating scale and the Western Ontario and McMaster Universities Arthritis Index 3.0 (WOMAC). Following treatment, the patient reported improvement in both pain and function as measured by the numerical pain-rating scale and WOMAC. MRI showed resolution of subchondral bone marrow bruising/oedema. No complications were noted. In this case report, PAPRP injections demonstrated improvement in all recorded outcome measures. Recognising the limitations of a single case report, the results highlight the need for more formal controlled trials to determine the potential use of PAPRP in the treatment of chondral lesions.

PMID:
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/23257268

TESTIMONIAL

December 2011

Osteo testimionial from a patient treated in Australia that lives in Vietnam.

Hi Peter,

I just couldn't wait to tell you the fantastic news! Today I walked for more than an hour for the first time in several years. It was more than 4km!

And two days ago I also walked for an hour around an old city in Vietnam, on uneven surfaces which has always been more difficult for me.

It's incredible how unused all my walking muscles are. The only thing that stopped me walking further today was not my knee, but all the muscles I was using to walk which have been dormant for such a long time. I'm also doing yoga every day and this seems to be helping too.

It's amazing because before I tried these long walks, I was thinking that the stem cells hadn't helped me at all. Now I realize it's all the other problems to do with my hip and other muscles which have seized up because I haven't been walking! And these seem to somehow impact on my ability to walk and pain associated with it. Just five days ago I lamented to Darrell that I didn't think the stem cells had worked at all because I was hobbling along like an old, old woman.

Now I can't wait to have the extra stem cell injection when I get back.

Anyway, let's see how the next injection of my own cells go and how long the benefits last. It seems that nobody is quite sure yet how long the benefit lasts and that older stem cells may have short lived benefits. Do you know anything about this? I gather not because nobody has been doing it long enough to really know.

Anyway, thankyou, thankyou so much for giving me back my mobility! Even for some time, if not permanently :)

Have a great Christmas and New Year.

Warmly
BB

PHOTOMODULATION

Photo Modulation
Perhaps the next generation of urilizing our own body's to self heal may utilize a low level laser applied to PRP or platelet rich plasma or bone marrow aspirate (BMAC). After the PRP is prepared and is an a syringe, it is then placed in a device that helps communicate the the cells & steer them towards an anti-inflammatory pathway.

The company AdiStem Ltd., which operates laboratories worldwide, has been researching how monochromatic light of various frequencies and intensities affects populations of mesenchyme stem cells and white blood cells in animals as well as in humans.

Photomodulation and photoactivation using low-level light is used to stimulate and control growth factors (the key component of PRP) in living cells. These lights block the pro-inflammation activity of proteins called cytokines. These Cytokines have been identified as key players in osteoarthritis and chronic tendon injuries and wounds.

Selecting the optimal photomodulaiton wavelength and bandwidth are critical in creating the ideal results. This light stimulation of cells results in the production or inhibition of ATP, which provides the cell with energy and proliferation.

AdiLight-1 is the first commercially available LED device for mesenchyme stem cell activation and the modulation of cytokine release.

Mesenchyme Stem Cells

When mesenchyme stem cells derived from adipose (fat) tissue are removed from a subject most of the cells will lie dormant. Stem cells and progenitor cells in the body are activated by a cascade of physiological processes such as the release of chemokines and growth factor from platelets in the blood. When photons from the AdiLight-1 act on stem cells derived from adipose for 20 minutes we observe an increase in integrin production, interleukin 1 recptor antagonist, thymosin beta 4, vascular endothelial growth factor, and of course, proliferation (see Figure 1). Most importantly the clinical results of the AdiLight-1 are consistent across age groups.

Mesenchyme Stem Cells
Figure 1. Colonies of stem cells derived from adipose - untreated (left). Colonies of stem cells derived from adipose after 20-minute AdiLight-1 exposure before plating (right).

Peripheral Blood White Blood Cells

Internal medicine specialists throughout Korea and Europe have been utilizing this therapy via photoactivation for many years. White blood cells, exposed to AdiLight-1 for 10-minutes show an anti-inflammatory cytokine response. (See Figure 2). We postulate that using the Adistem light therapy on prepared PRP may potentially result in less post injection pain and quicker recovery by guiding the cells to an anti vs pro-inflammation pathway. We find that some patients have more pain post treatment vs. others & this adjunct allows us to steer patients towards a more speedy recovery. More research is underway to better understand how laser light therapy may further assist our cells to heal.

Peripheral White Blood Cells
Figure 2. Results in four patients after a 10-minute exposure to AdiLight-1. Elisa assay for plasma interleukin 1 receptor antagonist peripheral WBCs before (left) and after (right).
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