Platelet Rich Plasma (PRP) is a cutting edge, new treatment in Cosmetic Therapies. Famous people like Angelina Jolie, Kim Kardashian and Madonna have all utilized Platelet Rich Plasma to help restore facial skin health. It utilizes part of the body’s natural regenerative process to accelerate and enhance healing. PRP is an autologous blood derivative, which means it’s a blood product obtained from you and then given back to you. This is an important principle in regenerative medicine.
Improved Skin Vitality, Pigment, Elasticity
|WHAT DOES PRP TREAT:|
|Acne Scarring||Stretch Marks||Brown Spots|
How It Works
Platelets in the blood are an integral part of forming clots, which stop bleeding. However they have another vital role in healing. They contain chemicals called growth factors, which have been shown to cause cells to multiply and form new tissue. PRP contains a much higher concentration of platelets than normal blood. This means that higher concentrations of growth factors are being released into the damaged area, which accelerates and enhances healing. PhotoActivated PRP engages the local tissue and activates the body’s own “Healing Cascade” which jump starts the natural regenerative process that is then carried on for months.
This isn’t a “quick fix”, as although you will look normal the next day, you won’t see a noticeable improvement. However, the body has started the process of rejuvenating your skin that will be apparent in weeks and continue for months.
A nurse will take your blood (as in a normal blood test), and spin it in a centrifuge, which separates the blood into two components. The bottom layer consists of red blood cells, while the top layer consists of plasma, regenerative cells, white blood cells and platelets. This top layer is the platelet rich plasma (PRP) that is removed for the treatment. The PRP is then PhotoActivated using AdiStem’s, Adi-Light technology. This entire process takes about 30 minutes. The PRP is then injected directly into the damaged areas.
Benefits for the Patient
Light activation of PRP has been shown to:
Before PRP Treatment
You should eat and drink healthily before a procedure. Avoid fatty foods, coffee and alcohol. Anti-inflammatory drugs (e.g. cortisone, nurofen, celebrex) should not be taken for 2 – 3 days before or after the treatment.
After PRP Treatment
Following treatment, you should rest and avoid harsh lotions or soaps. Limit the use of cosmetics for the first few days and avoid direct sunlight. You can expect gradual improvement in your skin condition in the following weeks.
PRP is taken from your own blood, so there is no risk of disease transmission or allergic reaction. PRP may cause a temporary increase in pain and swelling. There can be a localized pressure effect from the injection of fluid.
Length of Treatment
The required course of treatment is three (3) treatments one week apart. The treatment protocol takes two (2) weeks and skipping an injection means you have to start over again as the healing cascade will stop. IF after a month, you are not seeing results then you can try an additional single treatment to boost the cascade. after this you need to just let your body take it’s time and wait a few months.
Can Platelet-rich Plasma Be Used for Skin Rejuvenation? Evaluation of Effects of Platelet-rich Plasma on Human Dermal Fibroblast
Dae Hun Kim, M.D., Young Jin Je, M.S., Chang Deok Kim, Ph.D., Young Ho Lee, M.D.,1 Young Joon Seo, M.D., Jeung Hoon Lee, M.D., and Young Lee, M.D. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229934/
To summarize, the stimulation of dermal fibroblast proliferation by aPRP was demonstrated in this study. aPPP and aPRP increased type I collagen and MMPs gene expression, suggesting that aPRP and aPPP may have the potential to promote the remodelling of aged and photoaged skin. Considering limited studies on clinical efficacy and safety, further studies are required to investigate the mechanism and safety on autologous blood-derived PRP and PPP before clinical application.
Effect of platelet-rich plasma on ultraviolet b-induced skin wrinkles in nude mice
Jeong Mok Cho, Yoon Ho Lee, Rong-Min Baek, Sang Woo Lee Department of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Seoul, South Korea http://www.jprasurg.com/article/S1748-6815(10)00510-3/abstract
Although more in vivo studies and research about the mechanism of PRP are required, the results of this study indicate that PRP is effective in the rejuvenation of photoaged skin.
Effect of Platelet Rich Plasma on Photoaged Skin
Murad Alam, Professor of Dermatology, Northwestern University – June 1, 2011 http://clinicaltrials.gov/ct2/show/study/NCT01372566
The goal of this study is to assess the safety, tolerability and effectiveness of platelet rich plasma in the treatment of photoaged skin. This study will be divided into two parts. The first part will assess the safety and tolerability of platelet rich plasma injections as compared to sterile saline injections in subjects’ arm with six months follow-up. The second part will assess the effect of platelet rich plasma on the appearance of facial skin in a split face study with platelet rich plasma injections on one side of the face and sterile saline on the other. Outcomes will be recorded for twelve months.
Perhaps the next generation of urilizing our own body’s to self heal may utilize a low level laser applied to PRP or platelet rich plasma or bone marrow aspirate (BMAC). After the PRP is prepared and is an a syringe, it is then placed in a device that helps communicate the the cells & steer them towards an anti-inflammatory pathway.
The company AdiStem Ltd., which operates laboratories worldwide, has been researching how monochromatic light of various frequencies and intensities affects populations of mesenchyme stem cells and white blood cells in animals as well as in humans.
Photomodulation and photoactivation using low-level light is used to stimulate and control growth factors (the key component of PRP) in living cells. These lights block the pro-inflammation activity of proteins called cytokines. These Cytokines have been identified as key players in osteoarthritis and chronic tendon injuries and wounds.
Selecting the optimal photomodulaiton wavelength and bandwidth are critical in creating the ideal results. This light stimulation of cells results in the production or inhibition of ATP, which provides the cell with energy and proliferation.
This LED device for activation of both mesenchyme stem cells and the modulation of cytokine release.
Peripheral Blood White Blood Cells
Figure 1. Results in four patients after a 10-minute exposure to stem cell activation LED. Elisa assay for
plasma interleukin 1 receptor antagonist peripheral WBCs before (left) and after (right).
Internal medicine specialists throughout the USA, Thailand and Europe have been utilizing this therapy via photoactivation for many years. White blood cells, exposed to AdiLight-2 for 10-minutes show an anti-inflammatory cytokine response. (See Figure 1). We postulate that using the Adistem light therapy on prepared PRP may potentially result in less post injection pain and quicker recovery by guiding the cells to an anti vs pro-inflammation pathway. We find that some patients have more pain post treatment vs. others & this adjunct allows us to steer patients towards a more speedy recovery. More research is underway to better understand how light therapy may further assist our cells to heal.