• PhotoActivated PRP for Osteoarthritis and Joint Injuries, Knee Pain, Back Pain
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OSTEOARTHRITIS – JOINT PAIN
The following video is an actual procedure done to help alleviate the pain and discomfort associated with Osteoarthritis of the knee. The patients own fat stem cells have been isolated from their abdominal fat. They are then injected into the affected joint, in this case a knee. Here the stem cells will secrete cytokines and biochemical signals for months.

Resident or tissue specific stem cells in cartilage and other tissue in the knee will respond to these signals and start to multiply. This is called tissue regeneration. The process takes several months, but some patients report improvement in joint pain in several weeks. The procedure can also be performed on knees, ankles, shoulders, backs and hips. If stem cell banking is available, extra stem cells can be cryogenically stored and thawed out months or years later. Please inquire for more information on stem cell treatments in Bangkok, Thailand.

Osteo_fat_stem_cell_Feb_22_2012 Edit

 

Although stem cells sounds innovative and cutting edge, this therapy has been around for quite some time. In the past, these cells were very difficult and expensive to procure. With newer techniques and equipment, stem cells can easily be obtained and concentrated by a simple office procedure.

Stem cells are in people of all ages. Stem cells are the repairmen of the body. The most common is known as hematopoietic stem cells (HSC-CD 34+). The type of adult stem cell that is most often seen in research as being associated with tissue repair is a mesenchymal stem cell (MSC). These cells usually travel to the injured areas via the blood stream. If the injured area has a poor blood supply, this is called an area of hypoxia or low oxygen content. Areas of hypoxia include the joints, meniscus tissue, rotator cuff and other tendon injuries. These are areas that typically do not heal on their own. The body is not able to get enough of the repair cells to these injured areas. Since there is a poor blood supply in this area, the body has trouble sensing an injury is present.

MRi_of_Knee

 

Clear Clinical Evidence of Cartilage Regrowth After Adipose Stem Cell Treatment – Darker area indicates thickening of cartilage and generation of new cartilage.

Osteoarthritis (OA) is a progressive degenerative condition of articular cartilage and subchondral bone that affects 15% of the Australian population. The disease results in pain and stiffness that leads to significant physical and psychological disability, and adversely affects daily function and quality of life. Current treatment includes exercise, viscosupplementation and analgesia or anti-inflammatory medications however each of these is associated with limitations that restrict their ability to effectively arrest the condition. Consequently, there is a pressing need for novel and effective therapies to treat OA.

Recent research has demonstrated that Human adipose-derived stem cells (ADSCs) can differentiate into cartilage and bone suggesting a potential treatment in osteoarthritis (Diekman et al, 2010; Kern et al 2006). Indeed, cartilage regrowth has been shown in animal models with cartilage defects (Dragoo et al, 2007; Cui et al, 2009) and research in Humans has demonstrated its safety and efficacy in phase I and II clinical trials with up to two years follow up (Garcia-Olmo et al, 2005; Garcia-Olmo et al, 2008; Garcia-Olmo et al, 2009). Further, the sampling of cells from adipose tissue rather than bone marrow or human embryo tissue reduces the pain, complexity and ethical considerations associated with these other techniques. As such, the use of ADSCs may offer a safe and effective therapy to treat osteoarthritis and potentially reverse the progression of the disease.

RESEARCH – British Medical Journal – Published Peer Reviewed Clinical Evidence

Photoactivated Platelet-Rich Plasma Therapy for a Traumatic Knee Chondral Lesion 

Lifecare Prahran Sports Medicine Centre, Melbourne, Victoria, Australia.
Freitag J, Barnard A, Rotsein A.

Abstract 

To evaluate the effect of combining photoactivation therapy with platelet-rich plasma injections in the treatment of a traumatic chondral lesion of the knee. A 38-year-old man presented with left-knee pain and swelling following a basketball injury. MRI demonstrated a full-thickness lateral tibial plateau chondral flap with subchondral cyst formation and marrow oedema. The patient underwent a course of photoactivated platelet-rich plasma (PAPRP) injections. Patient outcome measures included the numerical pain rating scale and the Western Ontario and McMaster Universities Arthritis Index 3.0 (WOMAC). Following treatment, the patient reported improvement in both pain and function as measured by the numerical pain-rating scale and WOMAC. MRI showed resolution of subchondral bone marrow bruising/oedema. No complications were noted. In this case report, PAPRP injections demonstrated improvement in all recorded outcome measures. Recognising the limitations of a single case report, the results highlight the need for more formal controlled trials to determine the potential use of PAPRP in the treatment of chondral lesions.

PMID:
[PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/23257268

TESTIMONIAL FROM PATIENT RECEIVING ADIPOSE STEM CELL TREATMENT FOR KNEE PAIN

December 2014

Osteo testimionial from a patient treated with Adipose Stem Cells for Joint pain that lives in Vietnam. Treatment occurred in Bangkok, Thailand for Osteoarthritis.

Hi Peter,

I just couldn’t wait to tell you the fantastic news! Today I walked for more than an hour for the first time in several years. It was more than 4km!

And two days ago I also walked for an hour around an old city in Vietnam, on uneven surfaces which has always been more difficult for me.

It’s incredible how unused all my walking muscles are. The only thing that stopped me walking further today was not my knee, but all the muscles I was using to walk which have been dormant for such a long time. I’m also doing yoga every day and this seems to be helping too.

It’s amazing because before I tried these long walks, I was thinking that the stem cells hadn’t helped me at all. Now I realize it’s all the other problems to do with my hip and other muscles which have seized up because I haven’t been walking! And these seem to somehow impact on my ability to walk and pain associated with it. Just five days ago I lamented to Darrell that I didn’t think the stem cells had worked at all because I was hobbling along like an old, old woman.

Now I can’t wait to have the extra stem cell injection when I get back.

Anyway, let’s see how the next injection of my own cells go and how long the benefits last. It seems that nobody is quite sure yet how long the benefit lasts and that older stem cells may have short lived benefits. Do you know anything about this? I gather not because nobody has been doing it long enough to really know.

Anyway, thankyou, thankyou so much for giving me back my mobility! Even for some time, if not permanently :)

Have a great Christmas and New Year.

Warmly
BB

PHOTOMODULATION 

Perhaps the next generation of urilizing our own body’s to self heal may utilize a low level laser applied to PRP or platelet rich plasma or bone marrow aspirate (BMAC). After the PRP is prepared and is an a syringe, it is then placed in a device that helps communicate the the cells & steer them towards an anti-inflammatory pathway.

The company AdiStem Ltd., which operates laboratories worldwide, has been researching how monochromatic light of various frequencies and intensities affects populations of mesenchyme stem cells and white blood cells in animals as well as in humans.

Photomodulation and photoactivation using low-level light is used to stimulate and control growth factors (the key component of PRP) in living cells. These lights block the pro-inflammation activity of proteins called cytokines. These Cytokines have been identified as key players in osteoarthritis and chronic tendon injuries and wounds.

Selecting the optimal photomodulaiton wavelength and bandwidth are critical in creating the ideal results. This light stimulation of cells results in the production or inhibition of ATP, which provides the cell with energy and proliferation.

The LED device is used to activate mesenchyme stem cells and for the modulation of cytokine release.

 

Light_hitting_cell_Growth_Factors

Specific wavelengths of light can activate or turn on adipose stem cells or blood stem cells. This increases the secretions and healing signals released for the stem cells and allow them to communicate with resident stem cells in damaged tissue.

Mesenchyme Stem Cells

When mesenchyme stem cells derived from adipose (fat) tissue are removed from a subject most of the cells will lie dormant. Stem cells and progenitor cells in the body are activated by a cascade of physiological processes such as the release of chemokines and growth factor from platelets in the blood. When photons from the AdiLight-1 act on stem cells derived from adipose for 20 minutes we observe an increase in integrin production, interleukin 1 recptor antagonist, thymosin beta 4, vascular endothelial growth factor, and of course, proliferation (see Figure 1). Most importantly the clinical results of the AdiLight-1 are consistent across age groups.

  photomodulation-2
Figure 1. Colonies of stem cells derived from adipose – untreated (left). Colonies of stem cells derived from adipose after 20-minute
LED exposure before plating (right). 
Peripheral Blood White Cells Internal medicine specialists throughout the USA, Thailand and Europe have been utilizing this therapy via photoactivation for many years. White blood cells, exposed to an LED for 10-minutes show an anti-inflammatory cytokine response. (See Figure 2). We proved clinically that using the  light therapy on prepared PRP  results in less post injection pain and quicker recovery by guiding the cells to an anti vs pro-inflammation pathway. We find that some patients have more pain post treatment vs. others & this adjunct allows us to steer patients towards a more speedy recovery. More research is underway to better understand how laser light therapy may further assist our cells to heal.
photomodulation-3
Figure 2. Results in four patients after a 10-minute exposure to the LED. Elisa assay for plasma interleukin 1 receptor antagonist peripheral WBCs before (left) and after (right). 
The darker green indicates the presence of Anti-inflammatory compounds after exposure to LED, leading to less pain for the patient after PRP is injected into a painful joint. This also is seen with blood stem cell or adipose stem cell treatments.
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