Osteoarthritis (OA) is a progressive degenerative condition that affect the quality of life for many patients. The disease results in pain and stiffness that leads to significant physical and psychological disability, and adversely affects daily function and quality of life, often leading to surgery including hip and knee replacements. Now, biotechnology and adult stem cell therapy can offer safe and clinically proven cell therapies to patient with joint pain. These treatment use your own blood or can add adult stem cells to help heal your hip, knee, shoulder, back or neck. The latest EU and USA stem cell technologies are available in Bangkok, Thailand.
Recent research has demonstrated that Human adipose-derived stem cells (ADSCs) can differentiate into cartilage and bone suggesting a potential treatment in osteoarthritis (Diekman et al, 2010; Kern et al 2006). Indeed, cartilage regrowth has been shown in animal models with cartilage defects (Dragoo et al, 2007; Cui et al, 2009) and research in Humans has demonstrated its safety and efficacy in phase I and II clinical trials with up to two years follow up (Garcia-Olmo et al, 2005; Garcia-Olmo et al, 2008; Garcia-Olmo et al, 2009). Further, the sampling of cells from adipose tissue rather than bone marrow or human embryo tissue reduces the pain, complexity and ethical considerations associated with these other techniques. As such, the use of ADSCs may offer a safe and effective therapy to treat osteoarthritis and potentially reverse the progression of the disease.
RESEARCH- British Medical Journal
Photoactivated Platelet-Rich Plasma Therapy for a Traumatic Knee Chondral Lesion
Lifecare Prahran Sports Medicine Centre, Melbourne, Victoria, Australia.
Freitag J, Barnard A, Rotsein A.
To evaluate the effect of combining photoactivation therapy with platelet-rich plasma injections in the treatment of a traumatic chondral lesion of the knee. A 38-year-old man presented with left-knee pain and swelling following a basketball injury. MRI demonstrated a full-thickness lateral tibial plateau chondral flap with subchondral cyst formation and marrow oedema. The patient underwent a course of photoactivated platelet-rich plasma (PAPRP) injections. Patient outcome measures included the numerical pain rating scale and the Western Ontario and McMaster Universities Arthritis Index 3.0 (WOMAC). Following treatment, the patient reported improvement in both pain and function as measured by the numerical pain-rating scale and WOMAC. MRI showed resolution of subchondral bone marrow bruising/oedema. No complications were noted. In this case report, PAPRP injections demonstrated improvement in all recorded outcome measures. Recognising the limitations of a single case report, the results highlight the need for more formal controlled trials to determine the potential use of PAPRP in the treatment of chondral lesions.
Here is the Published Peer Review Clinical Evidence – have a look
PATIENT TESTIMONIAL – see Knee Pain for more patient testimonials on using adipose stem cells to treat painful joints and tendons.
Osteo testimionial from a patient treated using blood stem cells and PRP that lives in Vietnam and treated in Bangkok, Thailand.
I just couldn’t wait to tell you the fantastic news! Today I walked for more than an hour for the first time in several years. It was more than 4km!
And two days ago I also walked for an hour around an old city in Vietnam, on uneven surfaces which has always been more difficult for me.
It’s incredible how unused all my walking muscles are. The only thing that stopped me walking further today was not my knee, but all the muscles I was using to walk which have been dormant for such a long time. I’m also doing yoga every day and this seems to be helping too.
It’s amazing because before I tried these long walks, I was thinking that the stem cells hadn’t helped me at all. Now I realize it’s all the other problems to do with my hip and other muscles which have seized up because I haven’t been walking! And these seem to somehow impact on my ability to walk and pain associated with it. Just five days ago I lamented to Darrell that I didn’t think the stem cells had worked at all because I was hobbling along like an old, old woman.
Now I can’t wait to have the extra stem cell injection when I get back.
Anyway, let’s see how the next injection of my own cells go and how long the benefits last. It seems that nobody is quite sure yet how long the benefit lasts and that older stem cells may have short lived benefits. Do you know anything about this? I gather not because nobody has been doing it long enough to really know.
Anyway, thankyou, thankyou so much for giving me back my mobility! Even for some time, if not permanently
Have a great Christmas and New Year.
CASE REPORT – British Medical Journal – Blood Stem Cells and PRP for Osteoarthritis of the knee. Published Peer Reviewed Clinical Evidence.
To evaluate the effect of combining photo-activation
therapy with platelet-rich plasma injections for the
novel treatment of osteoarthritis
Julien Ben Freitag,1 Adele Barnard2
To evaluate the effect of combining photoactivation therapy with platelet-rich plasma injections for the novel treatment of osteoarthritis.
We present a case report of osteoarthritis of the knee treated with photo-activated platelet-rich plasma injections (PAPRP).
After utilising conventional osteoarthritis treatment methods a patient underwent a course of PAPRP injections. The patient outcome was measured using the numerical pain rating scale (NPRS) and the Western Ontario and McMaster Universities Arthritis
Following treatment the patient reported improvements in both pain and function as measured by the NPRS and WOMAC Index, respectively. The patient was followed up for 18 weeks, at which time no significant complications were noted.
In this case report of osteoarthritis, with strict control of conventional therapy variables, PAPRP injections demonstrated improvement in all recorded outcome measures. The results of this case report highlight the need to further investigate the use of
PAPRP in the treatment symptomatic knee osteoarthritis.
Pain reduction in patient with Osteoarthritis after PRP injection three sessions.
Published clinical evidence of improvement of Osteoarthritis using PRP for knee pain. Pain and stiffness reduced and function and mobility improved.