• Groundbreaking study uses stem cells as potential autism treatment
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AUTISM
This video covers a new and safe treatment for Autism. It uses umbilical cord stem cells to help repair and improve the symptoms of the child. It was conducted at Duke University in the United States and there were very solid clinical outcomes. This treatment is now available in Bangkok, Thailand.

Juvenile mesenchymal stem cells are prepared into a saline bag and given to the child through a simple saline drip. The stem cells will go to the areas they are needed. In many cases they will home in on the intestinal track and brain. Here, they will secrete cytokines and growth factors. This will signal the resident stem cells to proliferate, causing tissue regeneration. The child can receive multiple doses over a period of time. Duke University in the United States has successfully used cord blood stem cell to treat Autistic children with very solid clinical results. This is published peer reviewed scientific evidence of how adult stem cell can safely help your child.

The above shows 6 month improvement and 12 month improvement after the stem cell treatment for Autism. 10 patients were either very much improved or much improved 12 months later.

The above shows 6 month improvement and 12 month improvement after the stem cell treatment for Autism. 10 patients were either very much improved or much improved 12 months later.


Below is published peer reviewed research on using adult stem cells to treat autism.

Safety and Observations from a Placebo-Controlled, Crossover Study to Assess Use of Autologous Umbilical Cord Blood Stem Cells to Improve Symptoms in Children with Autism.

 

Chez M1,2, Lepage C1,2, Parise C2, Dang-Chu A2, Hankins A2, Carroll M3.
Author information
1- Pediatric Neuroscience, Sacramento, California, USA.
2- Sutter Institute for Medical Research (SIMR), Sacramento, California, USA.
3- Bone Marrow Transplant, Sutter Medical Group, Sacramento, California, USA.

Abstract
The aim of this exploratory study was to assess the safety and clinical effects of autologous umbilical cord blood (AUCB) infusion in children with idiopathic autism spectrum disorder (ASD). Twenty-nine children 2 to 6 years of age with a confirmed diagnosis of ASD participated in this randomized, blinded, placebo-controlled, crossover trial. Participants were randomized to receive AUCB or placebo, evaluated at baseline, 12, and 24 weeks, received the opposite infusion, then re-evaluated at the same time points. Evaluations included assessments of safety, Expressive One Word Picture Vocabulary Test, 4th edition, Receptive One Word Picture Vocabulary Test, 4th edition, Clinical Global Impression, Stanford-Binet Fluid Reasoning and Knowledge, and the Vineland Adaptive Behavior and Socialization Subscales. Generalized linear models were used to assess the effects of the response variables at the 12- and 24-week time periods under each condition (AUCB, placebo). There were no serious adverse events. There were trends toward improvement, particularly in socialization, but there were no statistically significant differences for any endpoints. The results of this study suggest that autologous umbilical cord infusions are safe for children with ASD. Tightly controlled trials are necessary to further progress the study of AUCB for autism. Stem Cells Translational Medicine 2018;7:333-341.


Stem Cells Transl Med. 2017 May;6(5):1332-1339. doi: 10.1002/sctm.16-0474. Epub 2017 Apr 5.

Autologous Cord Blood Infusions Are Safe and Feasible in Young Children with Autism Spectrum Disorder: Results of a Single-Center Phase I Open-Label Trial.

 

Dawson G1, Sun JM2, Davlantis KS1, Murias M1,3, Franz L1, Troy J2, Simmons R2, Sabatos-DeVito M1, Durham R2, Kurtzberg J2.

Author information
1- Duke Center for Autism and Brain Development, Duke University Medical Center.
2- Robertson Clinical and Translational Cell Therapy Program, Duke University Medical Center.
3- Duke Institute for Brain Sciences, Duke University Medical Center, Durham, North Carolina, USA.

Abstract
Despite advances in early diagnosis and behavioral therapies, more effective treatments for children with autism spectrum disorder (ASD) are needed. We hypothesized that umbilical cord blood-derived cell therapies may have potential in alleviating ASD symptoms by modulating inflammatory processes in the brain. Accordingly, we conducted a phase I, open-label trial to assess the safety and feasibility of a single intravenous infusion of autologous umbilical cord blood, as well as sensitivity to change in several ASD assessment tools, to determine suitable endpoints for future trials. Twenty-five children, median age 4.6 years (range 2.26-5.97), with a confirmed diagnosis of ASD and a qualified banked autologous umbilical cord blood unit, were enrolled. Children were evaluated with a battery of behavioral and functional tests immediately prior to cord blood infusion (baseline) and 6 and 12 months later. Assessment of adverse events across the 12-month period indicated that the treatment was safe and well tolerated. Significant improvements in children’s behavior were observed on parent-report measures of social communication skills and autism symptoms, clinician ratings of overall autism symptom severity and degree of improvement, standardized measures of expressive vocabulary, and objective eye-tracking measures of children’s attention to social stimuli, indicating that these measures may be useful endpoints in future studies. Behavioral improvements were observed during the first 6 months after infusion and were greater in children with higher baseline nonverbal intelligence quotients. These data will serve as the basis for future studies to determine the efficacy of umbilical cord blood infusions in children with ASD. Stem Cells Translational Medicine 2017;6:1332-1339.



Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder.

Abstract
BACKGROUND:
Autism spectrum disorder (ASD) is a frequent developmental disorder characterized by pervasive deficits in social interaction, impairment in verbal and nonverbal communication, and stereotyped patterns of interests and activities. It has been previously reported that there is vitamin D deficiency in autistic children; however, there is a lack of randomized controlled trials of vitamin D supplementation in ASD children.

METHODS:
This study is a double-blinded, randomized clinical trial (RCT) that was conducted on 109 children with ASD (85 boys and 24 girls; aged 3-10 years). The aim of this study was to assess the effects of vitamin D supplementation on the core symptoms of autism in children. ASD patients were randomized to receive vitamin D3 or placebo for 4 months. The serum levels of 25-hydroxycholecalciferol (25 (OH)D) were measured at the beginning and at the end of the study. The autism severity and social maturity of the children were assessed by the Childhood Autism Rating Scale (CARS), Aberrant Behavior Checklist (ABC), Social Responsiveness Scale (SRS), and the Autism Treatment Evaluation Checklist (ATEC).

TRIAL REGISTRATION NUMBER:
UMIN-CTR Study Design: trial number: UMIN000020281.

RESULTS:
Supplementation of vitamin D was well tolerated by the ASD children. The daily doses used in the therapy group was 300 IU vitamin D3/kg/day, not to exceed 5,000 IU/day. The autism symptoms of the children improved significantly, following 4-month vitamin D3 supplementation, but not in the placebo group. This study demonstrates the efficacy and tolerability of high doses of vitamin D3 in children with ASD.

CONCLUSIONS:
This study is the first double-blinded RCT proving the efficacy of vitamin D3 in ASD patients. Depending on the parameters measured in the study, oral vitamin D supplementation may safely improve signs and symptoms of ASD and could be recommended for children with ASD. At this stage, this study is a single RCT with a small number of patients, and a great deal of additional wide-scale studies are needed to critically validate the efficacy of vitamin D in ASD.

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