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Knee pain
Many famous athletes like Bartolo Colon and Tiger Woods have undergone this type of procedure with excellent results. The video shows how Adult Stem Cells and PRP can be used to treat golf related injuries to knees, shoulders and Joint Pain. A small amount of blood and abdominal fat is removed from the patient, stem cells are isolated, activated and injected into the golf injury. It usually takes about 6-8 weeks for complete healing to occur.

Knee pain is the most common orthopedic complaint and is a very big issue for suffers of this condition. It can be the result of many factors, including aging or common knee injury. It may also be the result of osteoarthritis or post surgery issues. The purpose of this page is help educate suffers of the various options using regenerative medicine. These include photoactivated platelet rich plasma ( PAPRP ), adipose ( fat ) derived stem cells and also blood stem cells. All are non-surgical options and are safe can clinically proven to be effective for many patients. Sometimes knee surgery is a necessary option, but these therapies can also be used in conjunction to accelerate healing and lessen scaring.

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Knee surgery may be the only option. However many patients have used adult stem cells, photoactivated PRP or blood stem cells to avoid surgery and lessen their pain.

How IS Photoactivated PRP made from your own blood to treat knee pain ?     prp_diagram-knee What kinds of clinical results can I expect from a series of 3 photoactivated PRP injections ?

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The above a clinical results of patients that received Photoactivated PRP, three injections for knee pain. Over 70% were satisfied with the non-surgical knee treatments.

What does my knee look like after treatment ?

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After three PAPRP injections to the knee the bone healed and patient saw reduction of knee pain without surgery.

KNEE PAIN

Knee Pain can often be caused by: overuse, sudden injury or an underlying condition.  Common degenerative conditions, such as osteoarthritis may drastically affect the knees, especially with age.  Depending on the cause, severity or the condition, there are a host of possible treatments. The symptoms of knee pain include swelling, redness, and stiffness.

Knee pain is the most common orthopedic complaint for those over 40 years old.  Until recently, knee surgery had been the only option for sufferers.

 

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Inflammation

Injuries produce inflammation that occurs where soft tissue, such as ligaments and tendons attaches to bone.  Inflammation is simply the result of injury caused by mechanics or formation of bone spurs (osteophytes) or extra fluids in the knee.  Swelling may be more pronounced after longer periods of inactivity.

Knee pain makes everyday activities, such as walking or climbing stairs quite difficult.  It is a common orthopedic site for chronic tissue degeneration that results in moderate to severe pain. With knee pain one may experience stiffness, swelling and often may find it difficult even to bend the knee to perform tasks. Unfortunately, this is why one may eventually resort to traditional surgery. Surgeries typically involve partial or total knee replacements. 

Orthopedic Regenerative Therapies

Bangkok Stem Cells offers various orthopedic regenerative therapies that use the body’s natural inflammatory process to reduce inflammation and the pain using non-surgical options that are safe and clinically proven to be effective for many patients. Sometimes knee surgery is a necessary option, but these therapies can also be used in conjunction to accelerate healing and lessen scaring.

 

Photo-activated Platelet Rich Plasma (PAPRP)

Platelet Rich Plasma (PRP) is a relatively new treatment for muscular, skeletal and orthopedic pain. It utilizes part of the body’s natural growth factors to accelerate and enhance healing. PRP is an autologous blood derivative, which means it’s a blood product obtained from you and then given back to you. It is a USFDA approved treatment since 1987.

Photoactivated Platelet Rich Plasma or PAPRP therapy may potentially result in less post injection pain and quicker recovery.  The light exposure guides the cells to an anti vs. pro-inflammation pathway. We find clinically that patients have less pain post treatment vs. other PRP therapies and allows a more speedy recovery.

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How will PAPRP Help?

Platelets in the blood are an integral part of forming clots, which stop bleeding.  They contain bio-chemicals called growth factors, which have been shown to cause cells to multiply and form new tissue. PRP contains a much higher concentration of platelets than normal blood that is being injected into the injured area and accelerates and enhances healing.

Pluripotent Blood Stem Cells  (PBSCs)

 Physicians and researchers use Regenerative Bio-medicine to enhance the effectiveness of current medical treatments and find ways to treat patients while avoiding the invasive procedures that characterize many other cell therapies. Bangkok Stem Cells technology partner has identified a new blood stem cell that holds the ability to differentiate to any human tissue or human cell structure.

Figure1. The above image shows the Pluripotent Blood Stem Cells that can be found in the patient’s own blood, isolated and activated for using in orthopedic applications.

Figure1. The above image shows the Pluripotent Blood Stem Cells that can be found in the patient’s own blood, isolated and activated for using in orthopedic applications.

 

The separation and activation of Pluripotent Blood Stem Cells or PBSCs from a simple blood draw produces a regenerative cell therapy that is the most advanced used to date.

How will Pluripotent Blood Stem Cells Help?

Very small embryonic like stem cells (VSELS) found in blood are very small and difficult to isolate.  The cells are activated or “woken up” using patented technology. Pluripotent blood stem cells are powerful cells, open to be a part of any human structure. In high concentrations in the blood stream, PBSCs lay dormant until an injury. Known as tissue regeneration, this therapy has been shown to retard and reverse the aging process.

Adipose (Fat) Stem Cell Therapies

Fat stem cells come from the patients own abdominal region where there are about 1-2 million stem cells and regenerative cells in 1 cc of pure fat. They are very powerful for orthopedic treatments and have been used in medicine since 1897.

A small amount of blood and abdominal fat is removed; stem cells are isolated, combined with PAPRP, activated and injected into the site of injury (6-8 weeks for noticeable pain reduction).

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How will Adipose (Fat) Stem Cells Help?

After stem cells are isolated from fat and injected into orthopedic sites, cytokines and biochemical signals are secreted for months.

Tissue specific cells in cartilage will respond to these signals and multiply or regenerate. Medical imaging shows stem cells “home in” on areas of injured or damaged tissue and activated stem cells secrete growth factors and signal resident stem cells to repair or regenerate the tissue.  The numbers of stem cells are not as important as the activation or secretions that coming off the patients own stem

Photoactivation

Photomodulation and photoactivation using low-level light is used to stimulate and control growth factors (the key component of PRP) in living cells. These lights block the pro-inflammation activity of proteins called cytokines. These Cytokines have been identified as key players in osteoarthritis and chronic tendon injuries and wounds.

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Selecting the optimal photomodulation, wavelength and bandwidth are critical in creating the ideal results. This light stimulation of cells results in the production or inhibition of ATP, which provides the cell with energy and proliferation.  Low level monochromatic lights have ben shown to have positive effects in stem cell and PAPRP therapies.

ARTHRITIS

Knee arthritis makes everyday activities, such as walking or climbing stairs quite difficult.  It is a common chronic degenerative condition that cause moderate to severe pain. With arthritis one may experience stiffness, swelling and often may find it difficult even to bend the knee to perform tasks. Unfortunately, this is why one with arthritis may eventually resort to traditional surgery. Surgeries typically involve partial or total knee replacements. A 2015 study by Harvard University of 12,000 patients found an 800% increase in heart attack one month after knee replacement surgery.

Lu, N., et al., “Total Joint Arthroplasty and the Risk of Myocardial Infarction – A General Population, Propensity Score-Matched Cohort Study.” Arthritis & Rheumatology Vol. 67, Issue 10, pages 2771–2779, October 2015.

The most common type of knee arthritis is osteoarthritis which   is a progressive wearing of cartilage at the knee joint.  Frequently after the age of 50, the age-related affects of osteoarthritis worsen causing continued overuse and wearing down of connective cartilage. 

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As with most orthopedic degenerative conditions symptoms become worse as the condition progresses.  Common treatments include: weight loss, strengthening exercises, wrapping, and pain relievers such as acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs).

Bangkok Stem Cells cell-based therapies have helped and offered relief too many patients who suffered from knee osteoarthritis and help them avoid a painful knee replacement.

Although there is no cure for arthritis of the knee, there are many treatment options available to help manage pain and keep people staying active.  Many patients have opted for adult stem cells, photo-activated PAPRP or blood stem cells to avoid questionable surgeries and reduce their pain.

LIGAMENT INJURY

 Ligaments connect thigh bones to lower leg bones while holding your bones in place and stabilizing the knee. Ligament damage (sprains and tears) are very often a result of sports injuries. Any of these injuries may result in severe knee pain with physicians recommending surgery.

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Medial collateral ligament (MCL) helps to protect and stabilize the knee joint against any blows or forces that may be directed on to the outer side of the knee. It helps to limit the amount that the knee moves from side to side.

Lateral collateral ligament (LCL) helps to protect and stabilize the knee joint against any blows or forces that may be directed on to the inner side of the knee. This ligament also helps to limit the amount the knee moves from side to side.

Anterior cruciate ligament (ACL) helps to stabilize the knee joint by controlling backward and forward movements of the knee. It stops the tibia bone from moving forwards in front of the femur.

Posterior cruciate ligament (PCL) helps to control the forward and backward movements of the knee.

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CARTILAGE INJURY

Cartilage damage is an injury often related to athletes and active sports professionals. A semi-hard (tough, but flexible) tissue, cartilage covers the end of your bones comprises two menisci on either side of the joint.  As a structure, menisci act as a structural integrity that stabilizes the knees under tension and torsion.

The medial meniscus is located on the inside of the knee and the lateral meniscus, positioned on the outside of the knee. A twisted knee refers to a tear in the knee cartilage which physicians may recommend surgery.

Lateral meniscus is the larger of the menisci that covers more surface area than the medial meniscus.  It can occasionally be injured or torn by twisting the knee or applying direct force often in sports or daily life.

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TENDON INJURY

The patella tendon is located just below the patella (knee cap). It has attachments on the patella and the tibial tuberosity on the tibia (shin bone).

Great levels of stress reaches the patella tendon during jumping and landing.

When stress is too great for the tendon it becomes stressed and sustains small micro tears. The tears encourage inflammatory markers and swelling ensues. 

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Bangkok Stem Cells provides premium technologies to AVOID painful surgeries and enhance long-term healing.

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Patella transfers the force of the quadriceps muscles as your knee straightens Designed to withstand repetitive loading.

Quadriceps Muscles provide an explosive contraction. It also helps to absorb the landing forces.

Testimonials

Patient Testimonial - Knee Pain, ankle pain, thumb pain, bursitis and stem cell treatment – a two time WINNER ! Adipose Stem Cell and PRP Treatment , joint pain, knee pain, thumbs, tendons, bursitis, ankle pain Jean D. 72 year old female, Pennsylvania ,USA Synopsis – February 22, 20162009 - I had been taking pain pills several times a day due to my knees swelling and having trouble walking, particularly on steps. My Orthopedic Surgeon had advised me in 2009 that since treating with steroids hadn’t worked to relieve my pain, he recommended I consider a double knee replacement. 2010 - At my son’s suggestion, I had my X-rays forwarded to Dr. Joe Purita, Regenerative Medicine in Boca Raton, FL on July 20, 2010. He suggested I have the Adistem procedure done in August 2010 using liposuction to remove some abdominal fat and inject Adipose stem cells into the knee joint. Dr. Joe treated my left knee in August, 2010. He dissolved the fat to leave my own stem cell pellet and activated them by passing the cells through an Adistem light frequency method. After injections of anesthetic into my knee joint, my stem cells were injected into my left knee. There was some swelling and pain afterwards in my knee but after a week, I was able to return to work without difficulty. I stopped taking pain pills regularly and have not had a problem with my left knee but for some occasional discomfort, especially when walking up or down a lot of stairs. 2015 - During a trip to Thailand, I started to have more trouble with my right knee. It began to swell and even caused swelling in my right ankle. I needed to take more and more pain pills. Although the right knee had started getting worse over time, this discomfort made me limp, and I now had great difficulty walking. Stairs were an exceptional struggle and painful to attempt. On Dec. 23rd, 2015, my son made an appointment for me to see Dr. Lewis, at a Bangkok Stem Cells approved Clinic in Bangkok. Dr. Lewis manipulated my joints, assessed my range of motion and determined the location of the problems and tested my current pain levels. My right knee was extremely painful to manipulate or move. The inside of my right and left knees (Pes) were painful to touch at a level 10 on a pain scale of 0-10. My right and left thumb joints were registering a 10 pain level when touched. My ankle was swollen and registered an 8 pain level. I could not lift my right knee, walk up or down steps, or use my thumbs without a great deal of pain. The doctor suggested treatment with Adipose stem cells and Photoactivated Platelet Rich Plasma (PAPRP). He used anesthetic to identify problem areas. He followed the Adistem protocol similar to what had been previously used on my left knee but included the PRP. Dr. Peter injected my own stem cells and PRP in multiple spots into 6 basic locations; inside my right and left knees (Pes), right knee joint, right ankle joint, and my right and left thumb joints. He also removed a lot of fluid from behind my right knee. There was minimal swelling or discomfort afterwards this time, no bruising, and I was walking more easily a day or two later. After about a week, I was able to travel and take a return flight on New Year’s Day from BKK to JFK on my own. My right ankle was not swollen or giving me any pain at all. I returned to work and healed and had slow improvement over the next few weeks. 2016 - By mid-February 2016, I surprised myself by walking upstairs without pain. I had increased my range of motion with my right leg, so that I was again able to lift my right knee over the tub to get in. My right and left thumbs no longer hurt to the touch, except for a small spot at the very bottom of my left thumb joint and that only registered a pain level of 1. Most of my joint discomfort is gone with only a 1 or 2 pain level sometimes. This is managed with over the counter pain relief, such as aspirin or ibuprofen occasionally. My quality of life has been favorably impacted by the ability to walk again comfortably. My pain has been greatly re-lieved by the stem cell and PRP therapy, and all this with no invasive surgery, dangerous drugs or harmful side effects. Thank you to all who cared and helped to make this amazing remedy possible.

Bangkok Stem Cells 

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The solution is in your stem cells

Intra-articular injection of photo-activated platelet-rich plasma in patients with knee osteoarthritis: a double-blind, randomized controlled pilot study

on Feb 9 , 2016

Abstract

BACKGROUND:

Improvements in knee osteoarthritis (OA) symptoms with platelet-rich plasma (PRP) have been attributed to its ability to modify intra-articular inflammatory processes. Photo-activation of peripheral blood also improves inflammatory mediators associated with OA, however combined photo-activated PRP (PA-PRP) has not been investigated. This pilot study assessed the feasibility, safety and symptomatic and functional change following injections of PA-PRP compared to hyaluronic acid (HA) in people with knee osteoarthritis (OA).

METHODS:

Thirty seven people with knee OA were enrolled in this double-blind randomized controlled pilot study set in a sports medicine clinic. Participants were randomly allocated to receive three injections of either PA-PRP or HA. The patients and the administering doctor were blinded to group allocation. Outcomes included recruitment and safety data, 100 mm visual analogue pain score (VAS), the Knee Osteoarthritis Outcome Score (KOOS), Knee Quality of Life (KQoL) scale, maximum hopping distance and number of knee bends in 30 s at four and 12 weeks.

RESULTS:

Twenty three (62 %) participants met the inclusion criteria, of which 12 (32 %) were randomized to the PA-PRP group and 11 (30 %) to the HA group. Two participants did not complete the intervention and two withdrew following their first assessment. Minor pain and swelling during the injection period was reported by two participants from the PA-PRP group. The PA-PRP group demonstrated significant improvements in the VAS (p < 0.01, ETA = 0.686), KOOS Pain (p < 0.05, ETA = 0.624), KQoL Physical (p < 0.05, ETA = 0.706) and KQoL Emotional subscales (p < 0.05, ETA = 0.715) at four and 12 weeks. The PA-PRP group also significantly improved hoping (p < 0.05, ETA = 0.799) and knee bends (p < 0.01, ETA = 0.756) at four or 12 weeks. The HA group showed improvements on only the KOOS Function subscale at 12 weeks (p < 0.01, ETA = 0.602). After controlling for baseline values, there were no significant between-group differences at either time-point.

CONCLUSIONS:

This study provides proof-of-concept evidence concerning the feasibility and safety of PA-PRP injections necessary to inform a larger clinical trial in people with knee OA. Our preliminary results also suggest PA-PRP improves self-reported pain, symptoms and lower extremity function, however no between-group differences were found. Photo-activated PRP may provide a safe and effective novel treatment for knee OA.

TRIAL REGISTRATION:

ACTRN12611000651987.

Keywords:  Cartilage, Pain, Arthritis, Musculoskeletal diseases

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